منابع مشابه
Integrins as architects of cell behavior
Integrins are cell surface receptors that bind cells to their physical external environment, linking the extracellular matrix to cell function. They are essential in the biology of all animals. In the late 1980s, we discovered that integrins are required for the ability of breast epithelia to do what they are programmed to do, which is to differentiate and make milk. Since then, integrins have ...
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Integrins form the major family of proteins that mediates cell-matrix interactions. As well as an adhesive function, it is increasingly apparent that integrins can transduce messages via classic signalling pathways and impact upon such fundamental cellular processes as proliferation, apoptosis, differentiation, and motility. Dysregulation of these processes are a feature of many malignancies. A...
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Cancer cell migration is a complex process that requires coordinated structural changes and signals in multiple cellular compartments. The nucleus is the biggest and stiffest organelle of the cell and might alter its physical properties to allow cancer cell movement. Integrins are transmembrane receptors that mediate cell-cell and cell-extracellular matrix interactions, which regulate numerous ...
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Fully exploiting the potential of on demand computing requires on demand business models. To respond “on demand” to the unpredicted opportunities of the moment, a business must invest in knowing earlier the meaning of what is happening now rather than in attempting to forecast better the opportunities of the future. This means concentrating on know-why, which is system knowledge, rather than kn...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2016
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e15-06-0369